Fibrinolytic poly(dimethyl siloxane) surfaces
Macromolecular Bioscience,
2008,
8,
863-870.
文章链接：http://dx.doi.org/10.1002/mabi.200800014
Fibrinolytic poly(dimethyl siloxane) surfaces
发布日期：2008-02-25
PDMS surfaces have been modified to confer both resistance to non-specific protein adsorption and clot lyzing properties. The properties and chemical compositions of the surfaces have been investigated using water contact angle measurements, ATR FT-IR spectroscopy, and XPS. The ability of the PEG component to suppress non-specific protein adsorption was assessed by measurement of radiolabeled fibrinogen uptake from buffer. The adsorption of plasminogen from human plasma to the various surfaces was studied. In vitro experiments 70 demonstrated that lysine-immobilized surfaces with free P-amino groups were able to dissolve fibrin clots, following exposure to plasma and tissue plasminogen activator.
