•  王宏炜
     副教授、硕士生导师
       

  • 联系方式

    Tel/ Fax+86-512-65880583
    Emailwanghw@suda.edu.cn
    Office苏州大学独墅湖校区912906


    个人简介

    1997-2002 中国科学院上海植物生理生态研究所 博士
    2002-2003 美国Johns Hopkins University 博士后
    2003-2008 武汉理工大学 副教授
    2008-2010 法国国家科学研究院蛋白质生物与化学研究所、Lyon 1 University 博士后
    2010年至今 苏州大学 副教授



    • 详细介绍

      研究领域:
      生物医用材料的分子生物学机理研究

      代表性论文: 

      1. Yingxian Zhao, Rui Jia, Yuping Liu, Xiang Shen, Hongwei Wang*, Lin Yuan*. Specific photothermal killing of cancer cells by RNase-conjugated glyco-gold nanoparticles. Materials Today Communications, 2021, 28, 102640.

      2. Shaoyu Cheng, Fei Yu, Benben Lu, Hongwei Wang* and Lin Yuan*. Promoting the neural differentiation of embryonic stem cells by using thermosensitive nanocomposites. Materials Advances, 2021, 2, 4380-4391.

      3. Xiuzhen Huang, Benben Lu, Yingxian Zhao, Zhiqiang Wang, Hongwei Wang* and Lin Yuan*. The antibacterial effect of bacteriophage-like gold nanoparticles. NANO: Brief Reports and Reviews, 2021, 16, 2150075.

      4. Fei Yu, Shaoyu Cheng, Jiehua Lei, Yingjie Hang, Qi Liu, Hongwei Wang*, Lin Yuan*. Heparin mimics and fibroblast growth factor-2 fabricated nanogold composite in promoting neural differentiation of mouse embryonic stem cells. Journal of Biomaterials Science, Polymer Edition, 2020, 31(13), 1623-1647.

      5. Zhenhua Li, Yuping Liu, Xuejin Huang, Changming Hu, Hongwei Wang*, Lin Yuan*, John L. Brash, Hong Chen. One-step preparation of gold nanovectors using folate modified polyethylenimine and their use in target-specific gene transfection. Colloids and Surfaces B: Biointerfaces 2019, 177, 306-312.

      6. Xuejin Huang, Zhenhua Li, Jingxian Wu, Yingjie Hang, Hongwei Wang*, Lin Yuan* and Hong Chen. Small addition of Zn2+ in Ca2+@DNA results in elevated gene transfection by aminated PGMA-modified silicon nanowire arrays. Journal of Materials Chemistry B, 2019, 7, 566-575.

      7. Ya Sun, Zhenhua Li, Jingxian Wu, Zhiqiang Wang, Yishi Dong, Hongwei Wang*, John L. Brash, Lin Yuan* and Hong Chen. Gold nanoparticle–protein conjugate dually-responsive to pH and temperature for modulation of enzyme activity. Journal of Materials Chemistry B, 2019, 7, 3260-3267.

      8. Zhiqiang Wang, Xiuzhen Huang, Sheng Jin, Hongwei Wang*, Lin Yuan * and John L. Brash. Rapid antibacterial effect of sunlight-exposed silicon nanowire arrays modified with Au/Ag alloy nanoparticles. Journal of Materials Chemistry B, 2019, 7, 6202-6209.

      9. Yuping Liu, Jinghong Wang, Xuejin Huang, Yingxian Zhao, Ya Sun, Sixuan Zhang, Hongwei Wang*, Lin Yuan,* and Hong Chen. Glutathione-sensitive silicon nanowire arrays for gene transfection. ACS Applied Materials & Interfaces, 2019, 11(50), 46515−46524.

      10. Zhenhua Li, Feng Liu, Yuqi Yuan, Jingxian Wu, Hongwei Wang*, Lin Yuan*, Hong Chen. Multifunctional gold nanoparticle layers for controllable capture and release of protein. Nanoscale, 2017, 9(40), 15407-15415.

      11. Jiehua Lei, Yuqi Yuan, Zhonglin Lyu, Mengmeng Wang, Qi Liu, Hongwei Wang*, Lin Yuan*, Hong Chen. Deciphering the role of sulfonated unit in heparin-mimicking polymer to promote neural differentiation of embryonic stem cells. ACS Applied Materials & Interfaces, 2017, 9 (34), 28209–28221.

      12. Feng Liu, Lulu Xue, Yuqi Yuan, Jingjing Pan, Chenjie Zhang, Hongwei Wang*, John L. Brash, Lin Yuan*, Hong Chen. Multifunctional nanoparticle-protein conjugates with controllable bioactivity and pH responsiveness. Nanoscale, 2016, 8, 4387 - 4394.

      13. Yuqi Yuan, Feng Liu, Lulu Xue, Hongwei Wang*, Jingjing Pan, Yuecheng Cui, Hong Chen, Lin Yuan*. Recyclable Escherichia colispecific-killing AuNP-polymers (ESKAP) nanocomposites. ACS Applied Materials & Interfaces, 2016, 8 (18), 11309-11317.

      14. Jingjing Pan, Yuqi Yuan, Hongwei Wang*, Feng Liu, Xinhong Xiong, Hong Chen, Lin Yuan*. Efficient transfection by using PDMAEMA modified SiNWAs as a platform for Ca2+-dependent gene delivery. ACS Applied Materials & Interfaces, 2016, 8(24), 15138-15144.

      15. Weikang Yang, Lijuan Zhu, Yuecheng Cui, Hongwei Wang*, Yanwei Wang, Lin Yuan*, Hong Chen. Improvement of site-directed protein-polymer conjugates: Highly bioactivity and stability using a soft chain transfer agent. ACS Applied Materials & Interfaces, 2016, 8 (25), 15967–15974.

      16. Yuecheng Cui, Zhenhua Li, Lei Wang, Feng Liu, Yuqi Yuan, Hongwei Wang*, Lulu Xue, Jingjing Pan, Gaojian Chen, Hong Chen, Lin Yuan*. One-step synthesis of glycoprotein mimics in vitro: improvement of protein activity, stability and application in the CPP hydrolysis. Journal of Materials Chemistry B, 2016, 4, 5437 – 5445.

      17. Hongwei Wang, Jingjing Pan, Hong Chen, Lin Yuan. Application of polyethylenimine-grafted silicon nanowire arrays for gene transfection. Methods in Molecular Biology, 2016, 1445, 279-287.

      18. Wenwen Jiang, Xiaoli Liu, Di Wu, Hongwei Wang*, Yanwei Wang, Hong Chen, Lin Yuan*. A simple, rapid one-step ELISA using antibody–antibody complex. Biotechnology and Applied Biochemistry, 2015, 62, 126-131. 

      19. Feng Liu, Yuecheng Cui, Lei Wang, Hongwei Wang*, Yuqi Yuan, Jingjing Pan, Hong Chen, Lin Yuan*. Temperature-responsive poly(N-isopropylacrylamide) modified gold nanoparticle-protein conjugates for bioactivity modulation. ACS Applied Materials & Interfaces, 2015, 7(21), 11547-11554.

      20. Yuecheng Cui, Feng liu, Xin Li, Lei Wang, Hongwei Wang*, Gaojian Chen, Lin Yuan, John L. Brash, Hong Chen*. Improvement in the thermal stability of pyrophosphatase by conjugation to poly(N-isopropylacrylamide): application to the polymerase chain reaction. ACS Applied Materials & Interfaces, 2015, 7 (39), 21913–21918.

      21. Lei Wang, Lin Yuan, Hongwei Wang*, Xiaoli Liu, Xinming Li, Hong Chen*. New strategy for reversible modulation of protein activity through site-specific conjugation of small molecule and polymer. Bioconjugate Chemistry, 2014, 25, 1252–1260.

      22. Min Tan, Hongwei Wang*, Yanyun Wang, Gaojian Chen, Lin Yuan*, Hong Chen. Recyclable antibacterial material: silicon grafted with 3,6-O-sulfated chitosan and specifically bound by lysozyme. Journal of Materials Chemistry B, 2014, 2, 569–576.

      23. Jingjing Pan, Zhonglin Lyu, Wenwen Jiang, Hongwei Wang*, Qi Liu, Min Tan, Lin Yuan*, Hong Chen. Stimulation of gene transfection by silicon nanowire arrays modified with polyethylenimine. ACS Applied Materials & Interfaces, 2014, 6, 14391–14398.

      24. Yajun Xu, Lei Wang, Wenwen Jiang, Hongwei Wang*, Jianlin Yao, Qinghua Guo, Lin Yuan*, Hong Chen. Silicon nanowire arrays - A new catalyst for the reduction of nitrobenzene derivatives. ChemCatChem, 2013, 5, 3788 – 3793.

      25. Hongwei Wang, Yanwei Wang, Lin Yuan*, Lei Wang, Weikang Yang, Zhaoqiang Wu, Dan Li, Hong Chen*. Thermally responsive silicon nanowire arrays for native/denatured-protein separation. Nanotechnology, 2013, 24, 105101.

      26. Hongwei Wang, Wenwen Jiang, Lin Yuan*, Lei Wang, Hong Chen*. Reductase-like Activity of silicon nanowire arrays. ACS Applied Materials & Interfaces, 2013, 5, 1800-1805.

      27. Hongwei Wang*, Wenwen Jiang, Yanwei Wang, Xiaoli Liu, Jianlin Yao, Lin Yuan, Zhaoqiang Wu, Dan Li, Bo Song, Hong Chen*. Catalase-like and peroxidase-like catalytic activities of silicon nanowire arrays. Langmuir, 2013, 29, 3-7.

      28. Hongwei Wang, Lin Yuan*, Tieliang Zhao, He Huang, Hong Chen*. Altered enzymatic activity of lysozymes bound to variously sulfated chitosans. Chinese Journal of Polymer Science, 2012, 30, 893-899. 

      29. Hongwei Wang, Lei Wang, Lin Yuan*, Weikang Yang, John L Brash, Hong Chen*. Inhibitory effect of silicon nanowires on the polymerase chain reaction. Nanotechnology, 2012, 23, 365101.

      30. Hongwei Wang, Lei Wang, Pengchao Zhang, Lin Yuan, Qian Yu, Hong Chen*. High antibacterial efficiency of pDMAEMA modified silicon nanowire arrays. Colloids and Surfaces B: Biointerfaces 2011, 83, 355-359.


       



 

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