• 李丹
    副教授
     
  • 联系方式

    Tel+86-0512-65880527
    Fax
    +86-0512-65880583
    Emaillidan@suda.edu.cn

    个人简介 本科(2002年9月~2006年7月)武汉理工大学,材料科学与工程学院,高分子科学与工程系
    博士(2006年9月~2011年7月)武汉理工大学,材料科学与工程学院
    访问学者(2007年9月~2008年9月)McMaster University,John Brash课题组
    工作经历 2011年7月至今苏州大学,材料与化学化工学部高分子科学与工程系
  • 详细介绍 研究领域:
    血液接触材料的制备及血液相容性研究
    蛋白质与材料表面的相互作用研究


    代表性论文

    As first author or corresponding author:

    1)         Tang Z, Luan Y, Li D*, Du H, Haddleton DM, Chen H*. Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor. Chemical Communications 2015;51:14263-6.

    2)         Liu Q, Li D*, Zhan W, Luan Y, Du H, Liu X, Brash JL, Chen H*. Surfaces having dual affinity for plasminogen and tissue plasminogen activator: in situ plasmin generation and clot lysis. Journal of Materials Chemistry B 2015;3:6939-44.

    3)         Tang Z, Li D*, Wang X, Gong H, Luan Y, Liu Z, Brash JL, Chen H*. A t-PA/nanoparticle conjugate with fully retained enzymatic activity and prolonged circulation time. Journal of Materials Chemistry B 2015;3:977-82.

    4)         Tang Z, Li D*, Luan Y, Zhu L, Du H, Tao Y, Wang Y, Haddleton DM, Chen H*. Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor “berth”. Chemical Communications 2015;51:10069-250.

    5)         Yang W, Tang Z, Luan Y, Liu W, Li D*, Chen H*. Thermoresponsive Copolymer Decorated Surface Enables Controlling the Adsorption of a Target Protein in Plasma. ACS Applied Materials & Interfaces 2014;6:10146-52.

    6)         Xu H, Luan Y, Wu Z, Li X, Yuan Y, Liu X, Yuan L, Li D*, Chen H*. Incorporation of Lysine-Containing Copolymer with Polyurethane Affording Biomaterial with Specific Adsorption of Plasminogen. Chinese Journal of Chemistry 2014;32:44-50.

    7)         Luan Y, Li D*, Wang Y, Liu X, Brash JL, Chen H*. I-125-Radiolabeling, Surface Plasmon Resonance, and Quartz Crystal Microbalance with Dissipation: Three Tools to Compare Protein Adsorption on Surfaces of Different Wettability. Langmuir 2014;30:1029-35.

    8)         Li D, Zheng Q, Wang Y*, Chen H*. Combining surface topography with polymer chemistry: exploring new interfacial biological phenomena. Polymer Chemistry 2014;5:14-24. (Review)

    9)         Zheng J, Li D*, Yuan L, Liu X, Chen H*. Lotus-Leaf-Like Topography Predominates over Adsorbed ECM Proteins in Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Surface/Cell Interactions. ACS Applied Materials & Interfaces 2013;5:5882-7.

    10)     Tang Z, Liu X, Luan Y, Liu W, Wu Z, Li D*, Chen H*. Regulation of fibrinolytic protein adsorption on polyurethane surfaces by modification with lysine-containing copolymers. Polymer Chemistry 2013;4:5597-602.

    11)     Li D, Wang S, Wu Z, Chen H*, Brash JL. A new t-PA releasing concept based on protein-protein displacement. Soft Matter 2013;9:2321-8.

    12)     郑军, 李丹*, 袁琳, 陈红. 表面接枝嵌段共聚物刷实现内皮细胞的选择性黏附. 高分子学报 2013;8:1108-14.

    13)     Li D, Chen H*. Regulation of protein/surface interactions by surface chemical modification and topographic design, p301-319 in “Proteins at Interfaces III: State of the Art”, Editors: Horbett T, Brash JL and Norde W, ACS Books 2012. (Book Charpter)

    14)     Li D, Chen H*, Wang S, Wu Z, Brash JL. Lysine-poly(2-hydroxyethyl methacrylate) modified polyurethane surface with high lysine density and fibrinolytic activity. Acta Biomaterialia 2011;7:954-8.

    15)     Li D, Chen H, Brash JL*. Mimicking the fibrinolytic system on material surfaces. Colloids and Surfaces B: Biointerfaces 2011;86:1-6. (Review)

    16)     李丹, 王莎莎, 郑军, 陈红*. 聚(甲基丙烯酸-2-羟乙酯)改性金表面用于构建生物检测基材. 高分子学报  2011;10:1188-94.

    17)     Li D, Chen H*, McClung WG, Brash JL. Lysine-PEG-modified polyurethane as a fibrinolytic surface: Effect of PEG chain length on protein interactions, platelet interactions and clot lysis. Acta Biomaterialia 2009;5:1864-71.

     

    As coauthor:

    1)         Zhan W, Shi X, Yu Q*, Lyu Z, Cao L, Du H, Liu Q, Wang X, Chen G, Li D, Brash JL, Chen H*. Bioinspired Blood Compatible Surface Having Combined Fibrinolytic and Vascular EndotheliumLike Properties via a Sequential Coimmobilization Strategy. Advanced Functional Materials 2015;25:5206-13.

    2)         Liu X, Yuan L, Li D, Tang Z, Wang Y, Chen G, Chen H*, Brash JL*. Blood compatible materials: state of the art. Journal of Materials Chemistry B 2014;2:5718-38. (Review)

    3)         Liu W, Wu Z*, Wang Y, Tang Z, Du J, Yuan L, Li D, Chen H*. Controlling the biointerface of electrospun mats for clot lysis: an engineered tissue plasminogen activator link to a lysine-functionalized surface. Journal of Materials Chemistry B 2014;2:4272-9.

    4)         Wang H*, Jiang W, Wang Y, Liu X, Yao J, Yuan L, Wu Z, Li D, Song B, Chen H*. Catalase-like and Peroxidase-like Catalytic Activities of Silicon Nanowire Arrays. Langmuir 2013;29:3-7.

    5)         Wang Y, Zhou F, Liu* X, Yuan L, Li D, Wang Y, Chen H*. Aptamer-Modified Micro/Nanostructured Surfaces: Efficient Capture of Ramos Cells in Serum Environment. ACS Applied Materials & Interfaces 2013;5:3816-23.

    6)         Wang S, Li D, Chen H*, Wu Z, Xu Y, Brash JL. A novel antithrombotic coronary stent: lysine-poly(HEMA)-modified cobalt–chromium stent with fibrinolytic activity. Journal of Biomaterials Science, Polymer Edition 2013;24:684-95.

    7)         Wang H, Wang Y, Yuan L*, Wang L, Yang W, Wu Z, Li D, Chen H*. Thermally responsive silicon nanowire arrays for native/denatured-protein separation. Nanotechnology 2013;24:105101.

    8)         Tang Z, Li D, Liu X, Wu Z*, Liu W, Brash JL, Chen H*. Vinyl-monomer with lysine side chains for preparing copolymer surfaces with fibrinolytic activity. Polymer Chemistry 2013;4:1583-9.

    9)         Zhou F, Yuan L*, Li D, Huang H, Sun T, Chen H*. Cell adhesion on chiral surface: The role of protein adsorption. Colloids and Surfaces B: Biointerfaces 2012;90:97-101.

    10)     Zhou F, Li D, Wu Z, Song B, Yuan L*, Chen H*. Enhancing Specific Binding of L929 Fibroblasts: Effects of Multi-Scale Topography of GRGDY Peptide Modified Surfaces. Macromolecular Bioscience 2012;12:1391-400.

    11)     Shi X, Wang Y, Li D, Yuan L*, Zhou F, Wang Y, Song B, Wu Z, Chen H*, Brash JL. Cell Adhesion on a POEGMA-Modified Topographical Surface. Langmuir 2012;28:17011-8.

    12)     Shi X, Li D, Xie J, Wang S, Wu Z, Chen H*. Spectroscopic investigation of the interactions between gold nanoparticles and bovine serum albumin. Chinese Science Bulletin 2012;57:1109-15.

    13)     Liu X, Wu Z*, Li D, Chen H. Poly(N-vinylpyrrolidone)-modified surfaces repel plasma protein adsorption. Chin J Polym Sci 2012;30:235-41.

    14)     Zhou F, Yuan L*, Wang H, Li D, Chen H*. Gold Nanoparticle Layer: A Promising Platform for Ultra-Sensitive Cancer Detection. Langmuir 2011;27:2155-8.

    15)     Yuan L, Yu Q, Li D, Chen H*. Surface modification to control protein/surface interactions. Macromolecular Bioscience 2011;11:1031-40. (Review)

    16)     Wu Z, Chen H*, Li D, Brash JL*. Tissue plasminogen activator-containing polyurethane surfaces for fibrinolytic activity. Acta Biomaterialia 2011;7:1993-8.

    17)     Zhang Y, Yu Q, Huang H*, Zhou F, Wu Z, Yuan L, Li D, Chen H*. A surface decorated with diblock copolymer for biomolecular conjugation. Soft Matter 2010;6:2616-8.

    18)     Liu X, Wu Z*, Zhou F, Li D, Chen H*. Poly(vinylpyrrolidone-b-styrene) block copolymers tethered surfaces for protein adsorption and cell adhesion regulation. Colloids and Surfaces B-Biointerfaces 2010;79:452-9.

    19)     Wu Z, Chen H*, Liu X, Zhang Y, Li D, Huang H. Protein Adsorption on Poly(N-vinylpyrrolidone)-Modified Silicon Surfaces Prepared by Surface-Initiated Atom Transfer Radical Polymerization. Langmuir 2009;25:2900-6.

    20)     Wu Z, Chen H*, Huang H, Zhao T, Liu X, Li D, Yu Q. A facile approach to modify polyurethane surfaces for biomaterial applications. Macromolecular Bioscience 2009;9:1165-8.

    21)     Chen H*, Zhang Y, Li D, Hu X, Wang L, McClung WG, Brash JL. Surfaces having dual fibrinolytic and protein resistant properties by immobilization of lysine on polyurethane through a PEG spacer. Journal of Biomedical Materials Research:Part A 2009;90A:940-6.

    22)     Chen H*, Yuan L, Song W, Wu Z, Li D. Biocompatible polymer materials: Role of protein-surface interactions. Progress in Polymer Science 2008;33:1059-87. (Review)

    23)     Chen H*, Wang L, Zhang Y, Li D, McClung WG, Brook MA, et al. Fibrinolytic poly(dimethyl siloxane) surfaces. Macromolecular Bioscience 2008;8:863-70.

    24)     Chen H*, Hu X, Zhang Y, Li D, Wu Z, Zhang T. Effect of chain density and conformation on protein adsorption at PEG-grafted polyurethane surfaces. Colloids and Surfaces B: Biointerfaces 2008;61:237-43.

 

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