Enhancing Specific Binding of L929 Fibroblasts: Effects of Multi-Scale Topography of GRGDY Peptide Modified Surfaces
Macromolecular Bioscience,
2012,
12,
1391-1400.
文章链接：http://dx.doi.org/10.1002/mabi.201200129
周峰同学在Macromolecular Bioscience发表研究论文
发布日期：2012-11-08
Surface chemical composition and roughness caused by micro/nano-topographical structures are two predominant factors in determining cellular response. A series of gold nanoparticle layers (GNPLs) with increasing surface roughness are prepared by depositing gold nanoparticles onto planar gold films. Glycine-arginineglycine- aspartic acid-tyrosine (GRGDY) peptide is then conjugated to the surface through poly- [oligo(ethylene glycol) methacrylate] polymer brushes as spacers. The pristine micro/nanoroughness structures significantly inhibit L929 cell growth. After modification with POEGMAGRGDY, however, the micro/nano-structures greatly enhance L929 cell-specific interactions while maintaining superior low-fouling ability compared to planar gold.
